Sleep and headache: a bidirectional relationship

Expert Review of Neurotherapeutics
January 2010, Vol. 10, No. 1, Pages 105-117 , DOI 10.1586/ern.09.135
(doi:10.1586/ern.09.135)
Review
Carlo Lovati†, Domenico D’Amico, Elisa Raimondi, Claudio Mariani and Pierluigi Bertora
†Author for correspondence

Sleep and pain perception are two phylogenetically well-conserved functions, strictly influenced by environmental and psychological factors, and are able to interact reciprocally both in physiological and pathological situations. Sleep and head-pain perception share the involvement of several structures, such as the thalamus, the hypothalamus and brainstem nuclei, including the locus coeruleus and raphe nuclei. There ais clinical evidence indicating that sleep disorders can precede the appearance of certain headaches and that head pain, especially when frequent, can, in turn, affect sleep quality. In the present work the anatomy, physiology and pathology of sleep and head-pain perception will be reviewed with the aim of highlighting the points of contact and possible unifying treatment strategies