Blood Pressure Changes in Migraine Patients before, during and after Migraine Attacks

Pain Practice Published Online: 11 Feb 2010 

ORIGINAL ARTICLE
Yaprak Seçil, MD*; Cem Ünde, MD*; Yeşim Yetimalar Beckmann, MD*; Yasemin Turan Bozkaya, MD † ; Filiz Özerkan, MD † ; Mustafa Başoğlu, MD*
  *Neurology Department, Atatürk Research and Training Hospital, † Cardiology Department, Ege University Medical School Hospital, Izmir, Turkey
Correspondence to Yaprak Seçil, MD, Oyak sitesi 2/10 sokak No:1/15, Üçkuyular, Izmir 35350, Turkey. E-mail: ysecil@gmail.com.
Copyright Journal compilation © 2010 World Institute of Pain

ABSTRACT
Migraine attacks are characterized by headaches associated with neurological, gastrointestinal, and autonomic symptoms. A relationship between migraine and hypertension or hypotension is controversial.

In this study, we aimed to determine if blood pressure changes were related to migraine attacks. From the outpatient clinic of our neurology department, 62 normotensive migraine patients with and without aura were chosen for study in accordance with the International Headache Society 2004 criteria. A questionnaire including general and specific questions was given to the patients to be filled out during 6 consequent migraine attacks. The patients received a fully automatic digital brachial upper arm sphygmomanometer (Omron M 4-1) to measure the changes in their blood pressure during attacks. The patients were asked to record their blood pressure changes 3 times: (1) just before or very early, (2) during (when headache peaks), and (3) 1 hour after the attack. Twenty-three of the 62 patients (57 women, 5 men) had migraine with aura (22 women and 1 man), and 39 of them did not have aura (35 women and 4 men). There was no statistically significant difference between systolic and diastolic values obtained before or very early, during the peak level, and 1 hour after the end of the attacks (P > 0.05). Although diastolic hypotensive values were not different statistically between groups, when all the patients were considered, diastolic hypotensive values were detected in a considerable number of patients (a total of 115 measurements). In this normotensive migrainous population, we observed that diastolic hypotension before or very early, during, and after migraine attack was the most significant result (5.1%).

Although it was not statistically significant, the total number of hypotensive values was remarkable.