P.F. Sowmanab, K. Wangbc, P. Svenssond, L. Arendt-Nielsenb
Received 7 April 2010; received in revised form 2 June 2010; accepted 8 June 2010. published online 08 July 2010.
Abstract
Tonic pain in one body segment can inhibit the perception of pain in another body segment. This phenomenon is mediated by diffuse noxious inhibitory controls (DNIC), and its efficacy in craniofacial regions is investigated in this study. A compressive device that evoked a tonic, moderate/severe, headache-like, conditioning pain (∼8/10 on a visual analogue scale) was applied for 15min. Eleven males participated in the study. Pressure pain threshold (PPT) and pressure pain tolerance (PPTol) at multiple heterosegmental body sites (right masseter, splenius capitis, second intermediate phalange, brachioradialis and tibialis anterior) were measured before, during and at multiple time points (5, 20 and 35min) after the termination of the conditioning pain. PPTs and PPTols were compared within participants across two experimental sessions; one that included painful conditioning stimulation, and a separate control session on a different day. Painful conditioning increased PPT significantly during pain over the masseter (p<0.05) and over the tibialis anterior (p<0.01). PPTol was unchanged. In the period after the painful conditioning stimulation PPT was depressed compared to control. This study shows that pain evoked from the craniofacial region evokes DNIC-like mechanisms on segmental as well as heterosegmental sites.
Corresponding author. Address: Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D-3, DK-9220, Aalborg, Denmark. Tel.: +45 99 40 88 30; fax: +45 98 15 40 08.
PII: S1090-3801(10)00142-4
doi:10.1016/j.ejpain.2010.06.009
© 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Inc. All rights reserved.
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